Micelle-Loaded Oral Dissolvable Strips: A Novel Strategy to Enhance Bioavailability and Pharmacokinetics of Therapeutics
Abstract
Background: This review examines the technology and therapeutic potential of oral dissolvable strips (ODS) loaded with micellized active pharmaceutical ingredients (APIs) for improved systemic drug delivery. Oral dissolvable strips (ODS) have emerged as a convenient and patient friendly route for drug delivery; however, many APIs exhibit poor aqueous solubility and stability, limiting their therapeutic efficiency. Micellar nanocarriers embedded in ODS can overcome these limitations by improving the solubility, stability, pharmacokinetics, and bioavailability. Objective: This review evaluates the integration of micelle technology with ODS platforms to improve systemic absorption and therapeutic performance of APIs, focusing on formulation advances, pharmacokinetic improvements, and translational challenges. Methods: Peer-reviewed research articles, patents, and reviews related to micellized APIs and oral film drug delivery systems were analyzed to identify formulation strategies, physicochemical optimization approaches, and clinical implications for diverse APIs. Results: Micelle-embedded oral films enable efficient delivery of hydrophobic drugs, produce faster absorption and achieve higher plasma concentrations than conventional oral routes. By improving patient compliance, minimizing toxicity, and protecting APIs from hepatic and gastrointestinal degradation, micelle/ODS systems significantly enhance bioavailability. Challenges exist with formulation variables such as…
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