Evaluation of orally disintegrating films containing ferulic acid inclusion complexes: Physical characteristics and release kinetics
Abstract
Orally disintegrating films (ODFs) has gained significant attention as a nutrient delivery platform due to its ease of intake. But studies on delivering ferulic acid (FA) through ODFs are still scarce. The objective of this study was to assess the physical characteristics of ODFs containing FA/β-cyclodextrin (0.5:1) (FA/β-CD (0.5:1)) and FA/hydroxypropyl-β-cyclodextrin (0.5:1) (FA/HP-β-CD (0.5:1)) complexes, as well as analyze the release kinetics of FA in both ODFs. Confirmation of the FA/β-CD (0.5:1) and FA/HP-β-CD (0.5:1) inclusion complexes was achieved through the reduction or attenuation of FA’s distinctive peaks in FT-IR and XRD examinations. Both the ODFs containing FA/β-CD (0.5:1) and FA/HP-β-CD (0.5:1) had a thickness of 0.06 mm, a surface pH of 6.7, and a disintegration time of less than 30 s, all of which met the requirements of ODFs effectively. The release of FA in both ODF formulations exhibited a high degree of consistency with the first-order kinetic model. Furthermore, the FA/HP-β-CD (0.5:1) ODF exhibited a higher cumulative release rate compared to the FA/β-CD (0.5:1) ODF throughout the entire in-vitro digestion process, indicating that FA/HP-β-CD (0.5:1) was more suitable for ODF formulation.
Read the paper
Related studies
- Improving the translation of search strategies using the Polyglot Search Translator: a randomized controlled trial
- Nutritional, Physical, Cognitive, and Combination Interventions and Frailty Reversal Among Older Adults: A Randomized Controlled Trial
- Clinical characteristics and risk factors associated with COVID-19 severity in patients with haematological malignancies in Italy: a retrospective, multicentre, cohort study
- A randomized, controlled trial of oral propranolol in infantile hemangioma
- Clinical phenotypes of delirium during critical illness and severity of subsequent long-term cognitive impairment: a prospective cohort study
- Increased physical activity improves sleep and mood outcomes in inactive people with insomnia: a randomized controlled trial
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.