ET&C Best Paper of 2023
Abstract
The development of the Genes-to-Pathways Species Conservation Analysis (G2P-SCAN), a novel R package designed to enhance the understanding of cross-species conservation of biological pathways, is a major leap forward toward integrating computational biology approaches into safety assessments. By integrating data from multiple databases and focusing on gene orthologs, protein families, entities, and reactions, G2P-SCAN offers a comprehensive tool for analyzing the conservation of biological processes across various species. This methodology supports the reduction of animal testing by enabling more accurate species extrapolation and risk assessment. The paper's significance lies in its potential to improve the accessibility and synthesis of genomic data, thus facilitating the application of mechanistically based data in ecological risk assessments. The authors demonstrate the utility of G2P-SCAN through five case studies, validating its effectiveness in identifying conservation and susceptibility at the pathway level across different species. This work not only advances scientific understanding but also aligns with global regulatory shifts towards new approach methodologies (NAMs), promoting the use of computational and cell-based approaches in safety assessments.
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