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A randomized controlled trial examining the effects of human models in e-cigarette advertisements and e-cigarette use among susceptible young adults

Lee DN, Pagano I, Mays D, Wagener TL, Stevens EM

Addictive behaviors, 2026

185 participants

Abstract

Background: The tobacco industry's aggressive marketing has driven e-cigarette use prevalence in young adults. Restricting appealing features - human models - from industry advertisements may reduce product appeal and discourage e-cigarette use in younger populations.

Design: We conducted a 2-arm parallel design randomized trial to examine the effects of regulating e-cigarette advertisements by removing human models and collected self-reported measures at 0, 4, 12, and 24 weeks.

Intervention: Susceptible young adults (N = 185; Mage = 22.5) were randomly assigned to the regulated or unregulated advertisement conditions and viewed an online magazine containing an e-cigarette advertisement every week for 24 weeks during the study.

Measures: The primary outcome was self-reported e-cigarette harm perceptions and use intentions, and salivary cotinine results assessed at 4, 12, and 24 weeks.

Results: Path analyses showed a sequential pathway, with harm perceptions partially mediating the relationship between viewing the unregulated (humans present) advertisement condition and increased intentions to use e-cigarettes (SRMR = 0.074, AGFI = 0.902, NNFI = 0.944).

Conclusions: The inclusion of human models in e-cigarette advertisements may reduce perceived e-cigarette harms over time, potentially increasing use intentions among susceptible young adults. Findings can inform the FDA and public advocacy initiatives to strengthen marketing regulations of tobacco products and reduce the…

How strong is the evidence?

Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 185 participants or records.

How the five levels of evidence work. The level is assigned automatically from the abstract and can be wrong, so check the paper.

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