The Role of Exogenous Factors in the Development and Clinical Course of Bronchial Asthma in Military Personnel under Current Conditions (Clinical Case)
Abstract
Bronchial asthma (BA) is a heterogeneous chronic inflammatory disease of the airways with a multifactorial pathogenesis involving exogenous, endogenous, epigenetic and stochastic factors in its formation and course. During ongoing military actions in Ukraine, the impact of exogenous factors has significantly increased, including chemical air pollutants, combustion products, particulate matter, bioaerosols, active and passive smoking of conventional and electronic cigarettes, as well as chronic psycho-emotional stress, all of which contribute to the development and exacerbation of BA.Objective — to analyse the influence of major exogenous triggers on the development, clinical course and control of BA under current conditions and to justify the need for a personalised multidisciplinary approach to patient management.Current scientific data on the mechanisms of airway injury induced by chemical and air pollutants, aeropollutants, components of tobacco smoke, EVALI (E-cigarette or Vaping Product Use-Associated Lung Injury), as well as the role of chronic psychophysiological stress in sustaining airway inflammation were summarised. It is shown that the combined effect of multiple exogenous triggers, limited access to maintenance therapy and reduced treatment adherence contributes to the development of uncontrolled or severe BA.A clinical case of BA with an unstable course that developing against the background of prolonged exposure to exogenous factors and psycho-emotional stress…
Read the paper
Related studies
- Tobacco and COPD: presenting the World Health Organization (WHO) Tobacco Knowledge Summary
- Comparative effects of e-cigarette smoking on periodontal status, salivary pH, and cotinine levels
- Association between exposure to environmental pollutants and increased oral health risks, a comprehensive review
- Influence of gestational window on offspring vascular health in rodents with in utero exposure to electronic cigarettes
- Natural products as kinase inhibitors in lung cancer: molecular mechanisms, therapeutic potential, and clinical trials
- Nicotine in electronic cigarettes
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.