Smoking cessation and harm reduction: a systematic overview of ongoing, randomized controlled trials
Abstract
Background: Smoking remains one of the major public health threats, necessitating substantial scientific and societal interest in further developing and implementing systematic, smoking cessation trials. This review examines ongoing randomized controlled trials (RCTs) on smoking cessation and harm reduction, focusing on adherence to German S3 guidelines for tobacco dependence and identifying areas needing further research and neglected aspects in the implementation of treatment guidelines for tobacco dependence.
Methods: A systematic search was conducted on the International Clinical Trials Registry Platform, comprising multiple trial registries worldwide, to identify ongoing RCTs focusing on smoking cessation and harm reduction. Utilizing the PICOS-scheme, we focused on trials targeting the general population, with biochemical verification, psychological counseling, telemedicine, and nicotine replacement therapy /smoking cessation medication or electronic nicotine delivery systems. Exclusion criteria included trials marked as "completed," "terminated," "unknown," or "withdrawn.".
Results: The review identified 30 ongoing RCTs, with a majority located in North America. A significant number of trials focus on socioeconomically disadvantaged or uninsured populations, while few address cancer survivors or individuals with smoking-related diseases. Nicotine replacement therapy or smoking cessation medication is consistently used across trials, but with varying regimens.…
How strong is the evidence?
Evidence Hub reads this as a systematic review, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
Read the paper
Related studies
- Tobacco and COPD: presenting the World Health Organization (WHO) Tobacco Knowledge Summary
- Comparative effects of e-cigarette smoking on periodontal status, salivary pH, and cotinine levels
- Association between exposure to environmental pollutants and increased oral health risks, a comprehensive review
- Influence of gestational window on offspring vascular health in rodents with in utero exposure to electronic cigarettes
- Natural products as kinase inhibitors in lung cancer: molecular mechanisms, therapeutic potential, and clinical trials
- Nicotine in electronic cigarettes
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.