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The Relationship between Environmental Tobacco Smoke Exposure and Decreased Lung Function in Adolescents : A Comprehensive Systematic Review

Nydia Ayu Ulima, Rajmil Shafira Salsabila

The Indonesian Journal of General Medicine, 2026

Abstract

Introduction: Environmental tobacco smoke (ETS) exposure remains a significant public health concern, particularly for adolescents whose lungs are undergoing critical development. Despite declining smoking rates in many countries, millions of adolescents worldwide continue to be exposed to ETS in their homes and communities. This systematic review aims to comprehensively evaluate the relationship between ETS exposure and decreased lung function in adolescents aged 10-19 years.

Methods: A systematic review was conducted following established guidelines. Twenty sources were included after screening based on predefined criteria: adolescent population age range (10-19 years), validated ETS exposure measurement, standardized lung function assessment, appropriate observational study design, focus on passive exposure, objective outcome measurement, and general population health status. Data extraction encompassed study characteristics, ETS exposure assessment methods, lung function measures, primary associations, effect sizes, dose-response evidence, effect modifiers, and confounding control.

Results: The predominant finding across studies was a negative association between ETS exposure and lung function parameters. Small airway measures (FEF25-75, FEF25) were most consistently affected, with He et al. reporting β = −0.104 (p=0.020) for FEF25-75 growth rate. FEV1 annual growth reduction of −0.34% (95% CI: −0.64% to −0.04%) was documented by Milanzi et al. Dose-response…

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