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Study finds varenicline can help young adults quit vaping

Alison Knopf

Alcoholism & Drug Abuse Weekly, 2025

261 participants

Abstract

Varenicline, a smoking cessation drug, can also help young adults quit vaping, according to a study by researchers from Mass General Brigham. The study, Varenicline for Youth Nicotine Vaping Cessation: A Randomized Clinical Trial, published in JAMA last week, showed that teenagers and young adults who took a varenicline pill twice a day were more than three times as likely to quit vaping as those who received only a text service. For the study, published in the Journal of the American Medical Association last week, researchers recruited 261 participants aged 16‐to‐25 into a randomized clinical trial. There were three groups.

How strong is the evidence?

Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 261 participants or records.

How the five levels of evidence work. The level is assigned automatically from the abstract and can be wrong, so check the paper.

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