Obstructive sleep apnoea and lung function, and their association with nocturnal hypoxemia: results from the Swedish CArdioPulmonary bioimage Study (SCAPIS) – a cross-sectional study
Abstract
Obstructive sleep apnoea (OSA) and its associations with lung function. Background OSA is highly prevalent and characterised by abnormal respiration during sleep. This large, population-based study aimed to investigate the associations between OSA and lung function in subjects aged 50–64 years. Method The population-based Swedish CArdioPulmonary bioimage Study includes information on anthropometry, comorbidities and spirometry. The current analysis included data from three centres (Gothenburg, Umeå and Uppsala) on whole-night respiratory polygraphy as a meta-analysis examining the overall effect size of lung function on sleep apnoea severity, expressed as ß-coefficient after stratifying for sex and adjusting for age, waist circumference and smoking status. Results Data from 9016 participants (54% women, age 58±4 years, body mass index 27±4 kg/m2 ) with sleep recordings of good quality were included in the final analysis. Forced expiratory volume during 1 s (FEV 1 ) (ß=−0.10 (95% CI −0.16 to −0.03)), forced vital capacity (FVC) (−0.15 (−0.21 to −0.10)) and diffusion capacity for carbon monoxide (DLCO ) (−0.08 (−0.10 to −0.05)) were all negatively associated with the oxygen desaturation index (ODI) and also with per cent of registration with nocturnal oxygen saturation <90% FVC (−0.44 (−0.87 to −0.01)), FEV 1 (−0.86 (−1.36 to −0.36)) and DL CO (−0.47 (−0.60 to −0.35)). Additionally, a positive association was observed between FEV 1 (0.13 (0.05 to 0.22)) and DL CO (0.07 (0.04…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 9,016 participants or records.
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