Oral nicotine pouches for cessation or reduction of use of other tobacco or nicotine products
Abstract
Abstract Rationale Oral nicotine pouches (ONP) emerged in the late 2000s, but have gained popularity since their introduction to the global market in 2016, with claims about their harm reduction potential. Objectives Primary objectives • To evaluate the benefits and harms of ONP when used to help people transition away from combustible tobacco use (smoking). • To evaluate the impact of ONP on the prevalence of combustible tobacco use. Secondary objectives • To evaluate the benefits and harms of ONP when used to help people transition away from other non‐combustible tobacco/commercial nicotine product use. • To evaluate the impact of ONP on the prevalence of use of other non‐combustible tobacco/commercial nicotine products. Search methods We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, and PsycINFO from 2000 to 13 January 2025. We also covered ClinicalTrials.gov and the WHO ICTRP through our search of CENTRAL. Eligibility criteria We included randomised controlled trials (RCTs) of ONP in people using tobacco or other non‐combustible tobacco/non‐pharmaceutical nicotine products. RCTs must have reported tobacco/nicotine use at 4+ weeks or biomarkers or adverse events at 1+ weeks. We also sought interrupted/multiple time‐series studies of ONP's population‐level effects on the prevalence of use of other tobacco/nicotine products. Outcomes Our critical outcomes were: smoking abstinence at 4+ weeks; number of people reporting serious…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 284 participants or records.
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