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Educational attainment and employment status in lung cancer patients: a nationwide study

Morten Borg, A. Løkke, M. Henriksen, S. Wen, R. Ibsen, O. Hilberg

Clinical and Translational Oncology, 2025

109,940 participants · 4 citations

Abstract

Lung cancer remains the leading cause of cancer-related deaths globally, with low-dose computed tomography (LDCT) screening widely implemented in several countries. However, current screening eligibility, based largely on the National Lung Cancer Screening Trial and NELSON trial outcomes, does not account for socioeconomic risk factors such as education and employment status, which may impact lung cancer incidence and outcomes. This study used data from the Danish National Patient Register to examine educational attainment and employment status among 109,940 lung cancer patients diagnosed between 1994 and 2018, compared to a randomly selected matched general population cohort. Patients were less likely to hold higher education degrees and more likely to be on disability pension compared to controls, underscoring a significant socioeconomic disparity. Lung cancer patients frequently had only primary school education, with this educational gap widening over time. Employment disparities were also noted, with lung cancer patients twice as likely to be on disability benefits. These findings suggest that socioeconomic vulnerabilities, including educational level and employment, may exacerbate lung cancer risk, possibly linked to higher smoking prevalence and occupational carcinogen exposure in lower socioeconomic groups. Targeted public health initiatives focusing on smoking cessation and LDCT access for socioeconomically disadvantaged individuals are crucial for addressing these…

How strong is the evidence?

Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 109,940 participants or records.

How the five levels of evidence work. The level is assigned automatically from the abstract and can be wrong, so check the paper.

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