Abstract SS03-01: Unraveling the genetic and environmental risk factors for lung adenocarcinoma in Asia
Abstract
In Asia, lung adenocarcinoma frequently occurs in never-smokers, and many of these tumors harbor EGFR mutations. This suggests that environmental and genetic factors promoting the development of lung cancer in never-smokers, or EGFR-mutant lung cancer, may be present in Asian populations. By performing whole-genome sequencing analyses of lung adenocarcinomas from never-smokers, passive smokers, and active smokers, we found that a substantial fraction of EGFR-positive lung adenocarcinomas arising in smokers lack the accumulation of SBS4 mutational signatures, representing so-called “molecular non-smokers.” In addition, passive smoking, a known risk factor for lung cancer in never-smokers, does not appear to be a risk factor for EGFR-mutant lung cancer (Mochizuki, JTO, 2024). These findings strongly suggest that factors other than smoking play a major role in the development of EGFR-mutant lung cancer. We have identified polymorphisms at the TERT and HLA class II loci as genetic factors that increase the risk of EGFR-mutant lung cancer. Based on these findings, we are currently investigating differences in the molecular properties of lung adenocarcinoma according to the distribution of these polymorphisms. In parallel, we are performing multi-omics analyses of early lung lesions in never-smokers, including adenocarcinoma in situ (AIS) and minimally invasive adenocarcinoma (MIA), with the aim of elucidating the mechanisms underlying the development of lung adenocarcinoma in…
Read the paper
Related studies
- Tobacco and COPD: presenting the World Health Organization (WHO) Tobacco Knowledge Summary
- Comparative effects of e-cigarette smoking on periodontal status, salivary pH, and cotinine levels
- Association between exposure to environmental pollutants and increased oral health risks, a comprehensive review
- Influence of gestational window on offspring vascular health in rodents with in utero exposure to electronic cigarettes
- Natural products as kinase inhibitors in lung cancer: molecular mechanisms, therapeutic potential, and clinical trials
- Nicotine in electronic cigarettes
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.