Anticancer Activity of a Poly-Herbal formulation ‘Tulsi & Licorice Herbal Green Tea’ on A549 Human Lung Carcinoma Cell Line
Abstract
Smoking tobacco has emerged as a growing concern among young adults in both urban and rural populations, with well-established correlations to lung cancer and respiratory diseases such as chronic bronchitis and Chronic Obstructive Pulmonary Disorders (COPD). Additionally, non-smokers face risks through passive smoking in their environments. In this context, traditional folklore medicine offers potential solutions, utilizing certain herbs known for their efficacy in treating bronchitis and other lung ailments. This research investigates the therapeutic potential of a polyherbal formulation, 'Tulsi-Licorice Herbal Green Tea,' composed of green tea leaves, Ocimum sanctum, Glycyrrhiza glabra, Adhatoda vasica, Solanum xanthocarpum, Zingiber officinale, Terminalia bellirica, Piper longum, Curcuma longa, and Quercetin. The study aims to explores its potential anticancer properties using A549 Human Lung Carcinoma cell lines and L132 Lung cell lines. Cell line studies revealed a notable toxicity of the 'Tulsi-Licorice Herbal Green Tea' on A549 Human Lung Carcinoma cells, with an IC50 value of 32 μg/ml, while L132 cells exhibited an IC50 of 40.4 μg/ml. Morphological examinations further demonstrated the formulation's ability to disrupt lung cancer cell structures, suggesting potential anticancer properties. Subsequent DNA degradation assays confirmed characteristics of apoptosis at the IC50 concentration. Tulsi & Licorice herbal green tea can be considered as potential anti-cancer…
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