C35-17 Prevalence of Type 2 High Inflammatory Phenotype COPD in an Irish Tertiary Referral Centre
Abstract
Chronic Obstructive Pulmonary Disease (COPD) places a significant burden on the Irish healthcare system accounting for 15,000 hospitalisations annually with over 380,000 patients living with the condition (1). The NOTUS (2) and BOREAS (3) trials demonstrated a reduction in COPD exacerbations in patients with eosinophils ≥300/µL with the anti-IL-4/13 dupilumab compared to placebo. Dupilumab has since been included in GOLD guidelines (4); however it has not yet been approved for this indication in Ireland. Mepolizumab has also been investigated for a similar patient cohort. The aim of this study was to investigate the prevalence of type 2 inflammation among patients with COPD presenting to the emergency department (ED) in a tertiary referral centre in Ireland and identify patients who could benefit from targeted therapy to reduce exacerbation burden.
Single center observational study looking at patients who attended the ED with COPD included in their presenting complaint between July 2024 -July 2025. Data collected included patient demographics, clinical presentation, age, sex, blood eosinophils, comorbidities, smoking status, treatment, and pulmonary function testing.
1103 patients attended the ED between July 2024 and July 2025 with COPD mentioned in their presenting complaint. This comprised 243 patients presenting with COPD exacerbations, requiring 380 hospital admissions. These patients had an average of 1.57 hospital admissions during this period. Average eosinophils…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 380,000 participants or records.
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