Statins Enhance the Efficacy of Pegylated Interferon-alpha2 in Patients with Ph-Negative Chronic Myeloproliferative Neoplasms. Results from a Danish Single-Institution Cohort Study
Abstract
Background: Chronic inflammation is an important driving force in the development and progression of myeloproliferative neoplasms (MPNs) in the biological continuum from the early MPN-stages - essential thrombocythemia (ET) and polycythemia vera (PV) - to the advanced myelofibrotic stage (MF). Statins are cholesterol-lowering drugs used for primary and secondary prevention of cardiovascular disease. In addition to cholesterol reduction, statins have demonstrated anti-proliferative, proapoptotic, anti-angiogenic, and anti-inflammatory properties. Several studies have investigated their impact on various types of cancer, including MPNs, demonstrating a reduction in the risk of cancer development and all-cause mortality. These pleiotropic effects of statins might be beneficial in the treatment of MPNs.
Aim: We aimed to investigate if statin use, in addition to standard cytoreductive treatment, entails a shorter time to obtain hematological and molecular responses, and with a lower dosage of cytoreductive drugs.
Method: The study was a single-institution, retrospective cohort study. We investigated a cohort of 126 patients diagnosed with MPNs at the Department of Hematology at Zealand University Hospital in Denmark from 2010-2023, including a JAK2V617F-subgroup consisting of all IFN-treated patients with the JAK2V617F mutation and ≥ 2 JAK2V617F variant allele frequency measurements (n = 34). All patients were diagnosed according to the WHO 2008 or 2016 classification of MPN.…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 126 participants or records.
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