71223 - Risk factors for severe complications and mortality in elderly undergoing colon surgery – a retrospective cohort study from the ERAS-registry
Abstract
The rising global population of older adults is expected to lead to more elderly individuals needing surgery for colon cancer. It's crucial to study risk factors for mortality and complications following colon surgery in this demographic.
The Swedish part of the ERAS-database (EIAS) from 2009 and 2022 was used. Patients aged ≥ 75 years undergoing colon surgery were compared with younger patients regarding basic characteristics and type of surgery. Possible risk factors for mortality and complications in the elderly group were analyzed using multivariate regression.
11 767 patients were included. After adjusting for available confounders, male gender, OR: 1.62; 95% CI: (1.23-2.14), ASA ≥ 3, OR: 1.59; 95% CI: (1.19-2.12), severe pulmonary disease, OR: 1.74; 95% CI: (1.03-2.95), recent immunosuppressive treatment, OR: 3.23; 95% CI: (1.61-6.47), diverticular disease as indication for surgery, OR: 2.78; 95% CI: (1.53-5.07) and open surgery, OR: 1.40; 95% CI (1.05-1.85) were significantly associated with severe complications in patients ≥ 75 years. Likewise, smoking, OR: 2.59; 95% CI (1.04-6.50), ASA ≥ 3, OR: 2.38; 95% CI (1.15-4.92), severe pulmonary disease, OR: 2.98; 95% CI (1.21-7.33), and open surgery, OR: 2.07; 95% CI (1.09-3.91) were significantly associated with mortality within 30 days in the elderly group.
Several risk factors for severe complications and mortality within 30 days of colon surgery in the elderly population were identified. Among these, severe pulmonary…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 11 participants or records.
Read the paper
Related studies
- Tobacco and COPD: presenting the World Health Organization (WHO) Tobacco Knowledge Summary
- Comparative effects of e-cigarette smoking on periodontal status, salivary pH, and cotinine levels
- Association between exposure to environmental pollutants and increased oral health risks, a comprehensive review
- Influence of gestational window on offspring vascular health in rodents with in utero exposure to electronic cigarettes
- Natural products as kinase inhibitors in lung cancer: molecular mechanisms, therapeutic potential, and clinical trials
- Nicotine in electronic cigarettes
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.