Preconception hypoglycemia and adverse pregnancy outcomes in Chinese women aged 20–49 years: A retrospective cohort study in China
Abstract
Background In addition to hyperglycemia, women with hypoglycemia identified during pregnancy have a higher risk of adverse pregnancy outcomes. However, there is limited evidence of the association between prepregnant hypoglycemia and adverse pregnancy outcomes in women without pre-existing diabetes. This study aims to explore the association between maternal preconception hypoglycemia and adverse pregnancy outcomes among childbearing-aged women in China. Methods and findings This was a retrospective cohort study of the National Free Preconception Checkup Project (NFPCP), including women who were aged 20–49, successfully conceived within one year without multiple gestations, and had complete information on pregnancy outcomes. Maternal fasting plasma glucose (FPG) concentrations were analyzed in the preconception examination stage, and women were divided into normal (FPG 3.9 to <5.6 mmol/L) and hypoglycemia (FPG < 3.9 mmol/L) groups. Adverse pregnancy outcomes included medical abortion, miscarriage or early stillbirth, preterm birth (PTB), macrosomia, low birth weight (LBW), large for gestational age (LGA), small for gestational age (SGA), birth defects, and perinatal death. Baseline characteristics of the two groups were balanced using inverse probability treatment weighting (IPTW) based on propensity scores. Both multivariable-adjusted and IPTW odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the association between preconception hypoglycemia…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 4,866,919 participants or records.
Read the paper
Related studies
- Tobacco and COPD: presenting the World Health Organization (WHO) Tobacco Knowledge Summary
- Comparative effects of e-cigarette smoking on periodontal status, salivary pH, and cotinine levels
- Association between exposure to environmental pollutants and increased oral health risks, a comprehensive review
- Influence of gestational window on offspring vascular health in rodents with in utero exposure to electronic cigarettes
- Natural products as kinase inhibitors in lung cancer: molecular mechanisms, therapeutic potential, and clinical trials
- Nicotine in electronic cigarettes
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.