A clinicopathological and molecular profiling study of EGFR mutations in a cohort of 215 lung cancer patients from Eastern India
Abstract
e20708
Background:
Epidermal Growth Factor Receptor (EGFR) mutations are a critical biomarker in non-small cell lung cancer (NSCLC), guiding targeted therapy decisions. While global prevalence and patterns are well-documented, regional variations influenced by genetic, environmental, and lifestyle factors necessitate localized studies. This study aimed to characterize the prevalence, patterns, and clinicopathological correlations of EGFR mutations in a lung cancer cohort from Eastern India.
Methods:
This observational study analyzed 215 lung cancer patients. Formalin-fixed paraffin-embedded (FFPE) tissues or blood samples were collected. DNA was extracted, and EGFR mutation analysis was performed using real-time PCR (TRUPCR EGFR kit). Clinicopathological data, including age, sex, smoking history, histology, and survival, were collected. Statistical analyses were performed using MS Excel and Friedman’s ANOVA. Survival analysis was conducted using Kaplan-Meier plots.
Results:
EGFR mutations were identified in 38% of patients. Exon 19 deletions were the most common mutation (39% of mutated cases). Mutations were more frequent in patients aged >60 years (62%), males (25% of total cohort), smokers, and those with adenocarcinoma. A significant proportion of mutated cases were found in smokers (52%) and passive smokers (24%). Systemic inflammatory markers (NLR, PLR) showed variations across exon mutation types. Survival analysis revealed a statistically significant improvement in…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 215 participants or records.
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