Experience of Pleurodesis with a 50% Glucose Solution in Patients with Secondary Pneumothorax: A Case Series
Abstract
Secondary pneumothorax commonly encountered and it often recurs or becomes a refractory to treatment.
Pleurodesis is usually selected for initial treatment in community hospitals. Recently, endobronchial intervention using
the endobronchial Watanabe spigot and endobronchial valve for refractory pneumothorax has become available, but
these procedures can be performed only at a few institutions with sufficient staff and equipment.
The use of a glucose solution for pleurodesis has been reported as a novel approach to persistent air leakage.
Pleurodesis with a 50% glucose solution was occasionally empirically performed in community hospitals. However,
only limited literatures have published. Here, I report the experience of five patients (4 men and 1 woman; 71 years
to 84 years old), seven times with inoperable secondary pneumothorax who received pleurodesis with a 50% glucose
solution. In our cases, two of them had pneumoconiosis, one had chronic obstructive lung disease (COPD), one had
interstitial pneumonia (IP) and one had lung cancer. The procedure successfully stopped air leakage and allowed chest
tube removal (4 days to 10 days) in three patients without severe complications. Same as previous report, temporary
hyperglycemia occurred in three patients. Therefore, pleurodesis with a 50% glucose solution suggested possibility
that a feasible and safe. Despite future large-scale studies should aim to examine the efficacy and tolerance of this
technique, it would be beneficial…
How strong is the evidence?
Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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