Non-small Cell Lung Cancer in Women: Experience From the National Institute of Oncology, Rabat, Morocco
Abstract
Introduction and aim Lung cancer is the most common cancer and the leading cause of cancer deaths worldwide; its incidence in the female population is increasing. The objective of this study was to describe the epidemiological, clinical, paraclinical, therapeutic and evolutionary profile of female patients with non-small cell lung cancer (NSCLC) and to research the predictive factors of better survival. Methods A retrospective cohort study was carried out among women with NSCLC, diagnosed between January 2019 and December 2023, at the National Institute of Oncology, Rabat, Morocco. The diagnosis was proven by pathological analysis of biopsy. Statistical analysis was carried out using Jamovi software version 2.5.3. Results We assessed 146 women (18.3%) among 805 cases with NSCLC; the average age was 63.5 ± 12.3 years. The percentage of non-smokers, passive smokers and active smokers was 87.7%, 7.5% and 4.8%, respectively. Cough (56.2%), chest pain (21.2%) and dyspnea (19.9%) were the major clinical signs. The common histological types were adenocarcinoma (90.4%), squamous cell carcinoma (6.8%) and other types (2.8%). The primary tumor site was in the right lung in 78 patients (53.4%), on the left in 65 cases (44.5%) and in three cases (2.1%) bilateral. Most patients, 87% (127 cases), were diagnosed at stage IV according to the TNM classification 8th edition. The epithelial growth factor receptor (EGFR) mutation test performed in 79 female patients (54% of cases) was positive…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 146 participants or records.
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