The effect of pharmaceutical composition based on L-carnitine on structural and functional features of rat placenta in the model of passive tobacco smoking
Abstract
Passive tobacco smoking in modern society is quite common phenomenon. Maternal smoking, including passive smoking, is one of the modifying risk factors for adverse pregnancy outcomes and is associated with disorders of the pregnant woman's reproductive system, including the development of placental dysfunction. The aim of this study was to investigate the effect of a pharmaceutical composition based on L-carnitine on the structural and functional features of the rat placenta in a model of passive tobacco smoking. The study was conducted on 40 nonlinear pregnant rats aged 6 months. Passive smoking modeling was performed from day 1 to day 20 of pregnancy. From the first day of gestation, daily for 20 days, rats were intragastrically administered a pharmaceutical composition based on L-carnitine at an effective dose of 25 mg/kg, and rats of the positive control group received the reference drug at a dose of 68 mg/kg. On the 20th day of pregnancy, the animals were withdrawn from the experiment to study the microstructure of the placenta and determine the level of sex hormones. Structural and functional changes in the rat placenta in the model of passive tobacco smoking were determined. The gravidoprotective effect of the pharmaceutical composition based on L-carnitine at a dose of 25 mg/kg in pregnant rats with a reproduced model of passive smoking was proved, which was manifested by a decrease in histomorphological and hormonal signs of fetoplacental insufficiency compared to…
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