Effect of smoking on CBC, exposure of PAH and oxidative stress biomarkers in rural population of district okara, pakistan
Abstract
Smoking is one of the global problems causing different disease. The health effects of smoking are widespread and well known. Smoking cause variation in different parameters of blood profile and exposure to PAHs causing oxidative stress among smokers. The aim of the study is to evaluate the effect of smoking on total blood count, exposure of PAHs and their association with oxidative stress biomarkers in rural population of district Okara. A total of 60 blood sample are collected, 30 males (15 smoker and 15 non-smoker), 30 females (15 smoker and 15 non-smoker); which is further subdivided into three groups based on the number of cigarettes smoked per day (active smoker, passive smoker and non-smoker). Blood samples were collected and subjected for the estimation of hematological parameters. Polycyclic aromatic hydrocarbons using HPLC, oxidative stress biomarkers (lipid peroxide, Superoxide dismutase and Catalase) using spectrophotometer. Among the smokers white blood cell and red blood cell increases and other hematological parameters such as MCV, MCHC, MCH, platelets increase while eosinophils, monocytes, E.S.R decrease. The level of PAHs in smoker increase as compared to non-smoker. The oxidative stress biomarkers in smokers MDA and CAT activity increase while decrease in SOD activity. The comparison between smoker male and smoker female or non-smoker male and non-smoker female shows mostly no significant difference (p>0.05). The comparison between smoker male and…
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