A long-term cost-effectiveness analysis of treatments for type 2 diabetes in portugal: once-weekly semaglutide 1 MG versus once-daily empagliflozin 25 MG
Abstract
Introduction: Management of type 2 diabetes includes aiming to maintain glycemic control, reduce cardiovascular events, with a low risk of hypoglycemic events and avoidance of weight gain. The present analysis assessed the long-term cost-effectiveness of once-weekly semaglutide 1 mg versus once-daily empagliflozin 25 mg for the treatment of patients with type 2 diabetes mellitus with inadequate glycemic control on metformin monotherapy from a healthcare payer perspective in Portugal. Methods: Long-term clinical and economic outcomes with once-weekly semaglutide 1 mg and oncedaily empagliflozin 25 mg were projected using the IQVIA CORE Diabetes Model. Clinical inputs in terms of patient characteristics and the impact of treatments on risk factors were based on an indirect comparison conducted using patient-level data from four randomized controlled trials as, to date, there is no head-to-head clinical trial comparing the two interventions. In the modeling analysis, both treatments were added to metformin and continued until glycated hemoglobin exceeded a threshold of 7.5%, at which point patients switched therapy to basal insulin. Pharmacy and complication costs, expressed in 2019 Euros (EUR), and utilities were applied. Future outcomes were discounted at 4% per annum. Results: Over simulated patient lifetimes, once-weekly semaglutide 1 mg was associated with increased life expectancy (12.80 vs 12.70 years) and quality-adjusted life expectancy (7.18 vs 6.98 quality-adjusted…
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Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
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