Evaluating Cardio-Protective Molecules by Efficacy Based on Weight Reduction and HbA1c Targets
Abstract
Background: The effectiveness of GLP-1 RAs and SGLT-2i classes, evaluated by a HbA1c target of Methods: A retrospective analysis was conducted on consecutively admitted out-patients of a tertiary care center for diabetes mellitus (DM) treatment from Romania, where 405 enrolled patients were evaluated at baseline, 6-, and 12-month visits. Results: SGLT-2i were superior to GLP-1 RAs and metformin, providing higher rates of combined target achievements-22.7% at 12 months, p Conclusions: This study shows real-world Romanian efficacy and over the time response of administering the new classes in T2DM patients when aiming for HbA1c < 7% levels and 5% BWR, with SGLT-2i outperforming metformin and GLP-1 RAs, emphasizing their growing role in the management of T2DM.
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