Hepatic restorative potential of Portulaca oleracea ethanolic extract and/or metformin in type II diabetes mellitus model induced by high-fat diet and STZ
Abstract
The risk of liver injury is increased by persistent hyperglycemia. Diabetes-related liver damage involves both oxidative stress and an abnormal inflammatory response. Nevertheless, many plants possess notable pharmaceutical properties, such as Portulaca oleracea (purslane, PE), which stands out for its wide range of potential medicinal applications globally. Consequently, this research sought to investigate the possibilities of purslane ethanolic extract in protecting against liver damage, oxidative stress, and the inflammatory response associated with diabetes. Diabetes was induced in rats through a high-fat diet, followed by a single intraperitoneal injection of 35 mg/kg of streptozotocin (STZ). The diabetic rats were treated with PE at dose of (100 mg/kg), metformin (MT) at dose of (100 mg/kg) or combination therapy of (50 mg/kg) PE plus (50 mg/kg) MT for 4 weeks. Prooxidants (TBARS, XO, and NO) levels, antioxidant enzymes activity (SOD and GPx), inflammatory markers (TNF-α, IL-1β, and IFN-γ), and hepatic architecture abnormalities were measured by using standardized protocols. Rats treated with STZ exhibited notable elevations in tissue prooxidants (TBARS, XO, and NO), and inflammatory markers (TNF-α, IL-1β, and IFN-γ), with a parallel reduction in the activity of tissue antioxidants (SOD and GPx). Severe histopathological include vacuolated hepatocytes, dilated congested central veins, and numerous apoptotic signs, in addition to histochemical alterations in the liver…
Read the paper
Related studies
- The Role of AMPK Activation for Cardioprotection in Doxorubicin-Induced Cardiotoxicity
- Hypoglycemic medicines in the treatment of Alzheimer’s disease: Pathophysiological links between AD and glucose metabolism
- Isorhamnetin Reduces Glucose Level, Inflammation, and Oxidative Stress in High-Fat Diet/Streptozotocin Diabetic Mice Model
- Modulating Sirtuin Biology and Nicotinamide Adenine Diphosphate Metabolism in Cardiovascular Disease—From Bench to Bedside
- Characterization of the SGLT2 Interaction Network and Its Regulation by SGLT2 Inhibitors: A Bioinformatic Analysis
- Early Treatment with Empagliflozin and GABA Improves β-Cell Mass and Glucose Tolerance in Streptozotocin-Treated Mice
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.