In silico evaluation of phytochemicals from mangifera indica against type 2 diabetes targets: a molecular docking and admet study
Abstract
Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder characterized by insulin resistance, impaired glucose regulation, and chronic hyperglycemia, which remains a major global health challenge.Unlike type 1 diabetes, which results from autoimmune-mediated β-cell destruction, T2DM is primarily associated with insulin resistance in peripheral tissues such as skeletal muscle, adipose tissue, and liver. This progressive condition involves multiple metabolic defects, including impaired incretin response, enhanced hepatic gluconeogenesis, and pancreatic β-cell exhaustion, which together lead to chronic hyperglycemia. On a global scale, the prevalence of T2DM has reached alarming proportions. Synthetic pharmacotherapies such as metformin, sulfonylureas, and thiazolidinediones have improved clinical outcomes but are often associated with limitations including side effects, high cost, and lack of multitarget efficacy. As a result, increasing attention has been directed toward natural phytochemicals with broad pharmacological activities. Mangifera indica (mango) is widely used in ethnomedicine for the management of diabetes, and its phytochemicals—including mangiferin, quercetin, catechins, and phenolic glycosides—have demonstrated promising antidiabetic effects. This systematic review, conducted in accordance with PRISMA guidelines, evaluated 114 eligible studies published between 2000 and 2022, integrating findings from molecular docking, ADMET profiling, in vitro assays,…
Read the paper
Related studies
- The Role of AMPK Activation for Cardioprotection in Doxorubicin-Induced Cardiotoxicity
- Hypoglycemic medicines in the treatment of Alzheimer’s disease: Pathophysiological links between AD and glucose metabolism
- Isorhamnetin Reduces Glucose Level, Inflammation, and Oxidative Stress in High-Fat Diet/Streptozotocin Diabetic Mice Model
- Modulating Sirtuin Biology and Nicotinamide Adenine Diphosphate Metabolism in Cardiovascular Disease—From Bench to Bedside
- Characterization of the SGLT2 Interaction Network and Its Regulation by SGLT2 Inhibitors: A Bioinformatic Analysis
- Early Treatment with Empagliflozin and GABA Improves β-Cell Mass and Glucose Tolerance in Streptozotocin-Treated Mice
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.