Clinical verification of levofloxacin mesylate vs levofloxacin

Jing Wang

Chinese Journal of New Drugs and Clinical Remedies, 2003

Abstract

AIM: To compare the efficacy and safety of levofloxacin mesylate with levofloxacin in the treatment of bacterial infections. METHODS: A randomized controlled clinical trial was conducted. One hundred and twenty six patients with bacterial infections were divided into two groups. Levofloxacin mesylate groups sixty three patients, (M 30, F 33, age (41± s 6) a); Levofloxacin group sixty three patients, (M 36, F 27, age (40±9) a). The two groups were orally given levofloxacin mesylate or levofloxacin 100 mg, tid, for 7 14 d, respectively. RESULTS: The total clinical effective rates were 89% (56/63) in levofloxacin mesylate group and 84% (53/63) in levofloxacin group. The bacterial clearance rates were 89% and 89%. The adverse reaction rates were 21%(13/63) and 18%(11/63), respectively. There was no statistical significance between two groups ( P 0.05 ). CONCLUSION: Levofloxacin mesylate and levofloxacin are effective and safe in the treatment of bacterials infections.

How strong is the evidence?

Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.

How the five levels of evidence work. The level is assigned automatically from the abstract and can be wrong, so check the paper.

Read the paper

• Publisher page

Related studies

• Ferulic acid regulates the AKT/GSK-3β/CRMP-2 signaling pathway in a middle cerebral artery occlusion animal model Laboratory Animal Research, 2013
• Novel Pharmacokinetic/Pharmacodynamic Parameters Quantify the Exposure–Effect Relationship of Levofloxacin against Fluoroquinolone-Resistant Escherichia coli Antibiotics, 2021
• Photochemical behavior of levofloxacin High Energy Chemistry, 2008
• Correlation Between Dissolution Profiles of Salt-Form Drugs in Biorelevant Bicarbonate Buffer and Oral Drug Absorption: Importance of Dose/ Fluid Volume Ratio Pharmaceutical Research, 2025
• Evaluation of the synergistic potential and mechanisms of action for de novo designed cationic antimicrobial peptides Heliyon, 2024
• Synthesis of [11C]levofloxacin Journal of Labelled Compounds and Radiopharmaceuticals, 2001

Go deeper in Evidence Hub

Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.

Open this study Sign up free