Preformulation study of Levofloxacin
Abstract
Levofloxacin is the L-isomer of the racemate ofloxacin, a quinolone antimicrobial agent. Chemically levofloxacin, a chiral fluorinated carboxyquinolone, is the pure (S)-enantiomer of the racemic drug substance Ofloxacin.Preformulation studies are needed to ensure the development of a stable as well as therapeutically effective and safe dosage form. The Preformulation studies, performed in this research include identification of drug, solubility analysis, partition coefficient and drug compatibility.In present work complete preformulation study was carried out, which include identification of drug, quantitative estimation of drug, solubility determination, melting point determination,partition coefficient determination etc.
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