140 Comparison of the Effects and Side Effects Between PDE-5 Inhibitors Combined with Dapoxetine and Single PDE-5 Inhibitor for Patients with Premature Ejaculation Comorbid Erectile Dysfunction
Abstract
Erectile dysfunction (ED) is common in patients with premature ejaculation (PE). Phosphodiesterase type 5 (PDE-5) inhibitors and dapoxetine can effectively treat ED and PE, respectively. However, PED-5 inhibitors can’t improve ejaculation control and dapoxetine can’t improve erectile dysfunction. It is controversial to how to treat PE comorbid ED. In this study, we aimed to compare the effect of combined sildenafil with dapoxetine and single sildenafil treatment and investigate the side effect of combination treatment. 42 patients with PE and secondary ED were treated in our center. 20 patients were administrated with sildenafil and dapoxetine, 22 patients with single sildenafil for 8 weeks. Data on premature ejaculation diagnostic tool (PEDT), self-reported intravaginal ejaculatory latency time (IELT), premature ejaculation profile (PEP), clinical global impression of change (CGIC) and International Index of Erectile Function-5 (IIEF-5) were recorded and compared between the combined treatment group and single treatment group before and after treatment.
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