MP47-02 dapoxetine inhibits erectile responses to stimulation of the cavernous nerve in rats: a NEW hypothesis for its effects on ejaculation
Abstract
You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Basic Research II1 Apr 2014MP47-02 DAPOXETINE INHIBITS ERECTILE RESPONSES TO STIMULATION OF THE CAVERNOUS NERVE IN RATS: A NEW HYPOTHESIS FOR ITS EFFECTS ON EJACULATION Stefano Palea, Celine Rouget, Philippe Lluel, and Julien Allard Stefano PaleaStefano Palea More articles by this author , Celine RougetCeline Rouget More articles by this author , Philippe LluelPhilippe Lluel More articles by this author , and Julien AllardJulien Allard More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.1455AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail Introduction and Objectives Selective Serotonin Reuptake Inhibitors (SSRI) like paroxetine and fluoxetine are known to induce erectile dysfunction in humans and rats. Dapoxetine, a selective SSRI, is approved in Europe for the management of premature ejaculation. The aim of this study was to assess the impact of dapoxetine on (1) erectile responses induced by electrical stimulation (ES) of the cavernous nerve and (2) on smooth muscle relaxations induced by sodium nitroprusside (SNP) or sildenafil (SF) in the isolated corpus cavernosum (CC). Methods Wistar rats were anaesthetized with urethane. The carotid artery, penis and jugular vein were catheterized for blood pressure and intracavernous pressure recordings (BP and ICP) and drug injection, respectively. The…
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