Effect of levofloxacin on renal function in elderly patients
Abstract
Objective:To study the effect of levofloxacin on renal function in elderly patients.Methods:Self-control and drug-control methods were used to observe the variations of renal function after levofloxacin(0.4g)or cefoperazone(3g～4g)were administed both twice daily intravenously for 7d～10d.Results:There were no significant differences in SCr BUN blood and urine β2-MG before and after treatment(P0.05),and there were no significant differences between the two groups too(P0.05).The indexes of renal function after therapy were better than that before therapy.Conclusion:The effect of disease state on renal function is much greater than that of drugs.Levofloxacin(0.4g,twice daily intravenously for 7d～10d)is safe and effective,and has no significant effect on renal function in elderly patients.
Read the paper
Related studies
- Ferulic acid regulates the AKT/GSK-3β/CRMP-2 signaling pathway in a middle cerebral artery occlusion animal model
- Novel Pharmacokinetic/Pharmacodynamic Parameters Quantify the Exposure–Effect Relationship of Levofloxacin against Fluoroquinolone-Resistant Escherichia coli
- Photochemical behavior of levofloxacin
- Correlation Between Dissolution Profiles of Salt-Form Drugs in Biorelevant Bicarbonate Buffer and Oral Drug Absorption: Importance of Dose/ Fluid Volume Ratio
- Evaluation of the synergistic potential and mechanisms of action for de novo designed cationic antimicrobial peptides
- Synthesis of [11C]levofloxacin
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.