Levofloxacin weight-adjusted dosing and pharmacokinetic disposition in a morbidly obese patient
Abstract
Sir, Obese patients may show differences in several pharmacokinetic parameters of many commonly used antimicrobials,1 and they often require a correction of the recommended dosages for non-obese subjects. Unfortunately, studies evaluating antimicrobial dosages in obese patients are limited and only a few are focused on patients with morbid obesity. Among fluoroquinolones, dosage recommendations are available only for ciprofloxacin, but data from these studies are contradictory.2,3 Levofloxacin is increasingly recommended in clinical guidelines for the treatment of respiratory infections, including pneumonia,4 and the lack of studies evaluating its plasma concentrations in obese patients can potentially result in treatment failures in this population. We have had the opportunity to study the basic pharmacokinetic/pharmacodynamic parameters of levofloxacin in a patient with severe morbid obesity. A patient in their mid-50s with severe morbid obesity (weight, 179 kg; height, 1.74 m; and body mass index, 56.2 kg/m2), chronic obstructive pulmonary disease and sleep apnoea–hypopnoea syndrome treated with nasal continuous positive airway pressure (CPAP) was admitted to an emergency department. The patient presented with an acute hypercapnic respiratory failure secondary to a lower respiratory tract infection and cocaine abuse. On admission, the chest X-ray did not show opacities. Blood test results were: serum creatinine, 73.37 μmol/L; creatinine clearance, 78 mL/min; leucocyte…
Read the paper
Related studies
- Ferulic acid regulates the AKT/GSK-3β/CRMP-2 signaling pathway in a middle cerebral artery occlusion animal model
- Novel Pharmacokinetic/Pharmacodynamic Parameters Quantify the Exposure–Effect Relationship of Levofloxacin against Fluoroquinolone-Resistant Escherichia coli
- Photochemical behavior of levofloxacin
- Correlation Between Dissolution Profiles of Salt-Form Drugs in Biorelevant Bicarbonate Buffer and Oral Drug Absorption: Importance of Dose/ Fluid Volume Ratio
- Evaluation of the synergistic potential and mechanisms of action for de novo designed cationic antimicrobial peptides
- Synthesis of [11C]levofloxacin
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.