Effect of Terazosin on the Pharmacokinetics of Levofloxacin in the Rat Model of Prostatitis
Abstract
The primary objective of the present work was to investigate the effect of terazosin on the pharmacokinetics of levofloxacin in prostate, when combined therapy of terazosin hydrochloride and levofloxacin were applied to treat bacterial prostatitis in the rat. A total of 100 rats with bacterial prostatitis were randomized into the control group and the research group, with 50 rats in each group. Levofloxacin solution was injected intravenously to the rats of both groups. Terazosin hydrochloride solution was given by gavage to the rats of the research group, while solvent was administrated by gavage to the rats of control group. After drug administration, the rat prostate was harvested and homogenized and the levofloxacin concentration was analysed. The drug-time curves in both groups were accorded with two compartments model. Compared with the control group, the t½β, Cmax and AUC0–12 was significantly higher in the research group. And there was significant difference in the levofloxacin concentration of prostate between both groups (p<0.05). The levofloxacin concentration and distribution were significantly elevated by terazosin hydrochloride, which could improve the prognosis of prostatitis and obtain better therapeutic efficacy.
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