Polymer Coated Ovalbumin Nanoparticles loaded Levofloxacin Preparation for the Improved Antibacterial Activity
Abstract
Among the different type of metallic and non metallic nanoparticles, polymeric nanoparticles based on protein are highly attractive because of their best biocompatibility, high rate of drug loading and entrapment efficacy which would offer protein based nanoparticles as the major drug delivery system. In the present study, ovalbumin nanoparticles coated with polymer incorporated levofloxacin drug nano conjugate was prepared and the synthesized nano conjugate was evaluated against improved antibacterial activity against pathogenic bacteria. Cocervation method was carried out to synthesize Ovalumin nanoparticles and the prepared particles were coated with the polymer followed by loading of levofloxacin. Synthesized nano drug conjugate revealed spherical nano sized spheres with the size range of 80-90nm. Fourier transform infrared spectroscopy (FTIR) study showed specific changes in absorption peaks. Antibacterial activity study against human pathogenic bacteria showed an increase in zone of inhibition on solid plate assay and least minimum inhibition concentration on liquid assay against the tested bacterial strains. Further study of controlled release and target delivery using suitable animal model is in progress.
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