Effect of mirabegron, tamsulosin, and tadalafil on quality of life in patients with indwelling ureteral (double-J) stents
Abstract
OBJECTIVE
To evaluate and compare the efficacy of mirabegron, tamsulosin, and tadalafil in improving stent-related symptoms and overall quality of life in urological patients following JJ stent insertion.
METHODS
During the period from January 2022 to December 2022, 131 patients with ureteral double-J stents were randomly assigned two days post-insertion to receive either mirabegron (50 mg daily), tamsulosin (0.4 mg daily), or tadalafil (5 mg daily) for two weeks. Stent-related symptoms and health-related quality of life were assessed at baseline and at two weeks using the validated Ureteral Stent Symptom Questionnaire (USSQ). All groups completed follow-up.
RESULTS
The tamsulosin group showed the greatest improvement in total USSQ score (P ≤ .001), with significantly lower urinary symptoms, general health, and sexual function scores than the mirabegron and tadalafil groups. Specifically, sexual matter scores [median (IQR)] were lowest in the tamsulosin group [5 (1)] versus tadalafil [7 (3.2)] and mirabegron [16.5 (11)] (P ≤ .001). Differences in work performance and additional problem domains were not significant. Adverse effects were mild: dizziness/hypotension (∼6% tamsulosin), palpitations/headache (∼4% mirabegron), and flushing/dyspepsia/back pain (∼10% tadalafil). No serious events occurred, and no patient discontinued therapy.
CONCLUSION
In conclusion, tamsulosin produced the most comprehensive symptom relief supporting its use as first-line therapy for patients with…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
Read the paper
Related studies
- Protective effects of tadalafil and N-acetyl cysteine therapy on cisplatin-induced testicular toxicity
- Understanding and treating ejaculatory dysfunction in men with diabetes mellitus
- An Eco-Friendly Solid-State Electrode Modified With ZnO Nanoparticles Decorated With MWCNT as an Electrochemical Sensor for the Determination of Avanafil in Pure Form, Dosage Form and Human Plasma
- The Use of Generative AI for Scientific Literature Searches for Systematic Reviews: ChatGPT and Microsoft Bing AI Performance Evaluation
- Combinations of Freeze-Dried Amorphous Vardenafil Hydrochloride with Saccharides as a Way to Enhance Dissolution Rate and Permeability
- Return to Sport, Reinjury Rate, and Tissue Changes after Muscle Strain Injury: A Narrative Review
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.