A Letter to the Editor Concerning the Meta-Analysis by Zhou et al: Meta-Analysis of the Long-Term Efficacy and Tolerance of Tadalafil Daily Compared With Tadalafil On-Demand in Treating Men With Erectile Dysfunction
Abstract
The conclusion regarding the superiority of daily usage in comparison with tadalafil on demand was drawn by the analysis of the IIEF-EF questionnaire and the response to questions 2 (Sexual Encounter Profile [SEP2]) and 3 (SEP3) of the SEP Diary. In the results section, the authors reported that the tadalafil daily group had a greater increase of IIEF-EF (MD 1⁄4 1.24; 95% CI 1⁄4 0.03e2.44; P 1⁄4 0.04), SEP2 (MD 10.08; 95% CI 1⁄4 9.15e11.01; P < 0.00001) and SEP3 (MD 8.19; 95% CI 1⁄4 2.09e14.29; P < 0.00001) in comparison tadalafil on demand, which suggest the superiority of tadalafil daily. However, when we analyze the forests plots figures, we observe the opposite results: this greater improvement described in the tadalafil daily group is actually observed in tadalafil on-demand group.
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