The Efficacy and Safety of Tamsulosin and Tadalafil Combination Therapy Compared with Tadalafil Alone for Patients with Benign Prostatic Hyperplasia
Abstract
Background: Benign prostatic hyperplasia (BPH) is a common urologic condition in aging men that often manifests as lower urinary tract symptoms (LUTS). Pharmacological management includes α1-adrenoceptor blockers like tamsulosin and phosphodiesterase type 5 inhibitors (PDE5-Is) like tadalafil. Recent studies suggest combination therapy may offer greater symptom relief. Objective: To compare the efficacy and safety of combination therapy with tamsulosin and tadalafil versus tadalafil monotherapy in patients with BPH-related LUTS. Methods: This literature review included randomized controlled trials and prospective studies published between 2008 and 2022. Databases such as PubMed, MEDLINE, Embase, and Cochrane Library were searched using relevant keywords. Twelve studies met the inclusion criteria and were narratively analyzed. Results: Most studies showed that combination therapy was more effective than monotherapy in improving IPSS scores, Qmax, and sexual function, especially in patients with coexisting erectile dysfunction. Fixed-dose combination therapy also improved patient adherence and satisfaction. While tadalafil monotherapy remained effective, particularly in men with mild-to-moderate symptoms, its effect was less consistent in severe LUTS. Conclusion: Combination therapy of tamsulosin and tadalafil provides superior clinical benefit in managing LUTS/BPH, especially in men with concurrent ED. It is generally well tolerated, but individualized therapy based on…
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Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
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