Non-Invasive Positive Pressure Ventilation (NIPPV) in the Pregnant Patient: A Case Series
Abstract
Rationale: Acute respiratory failure is an uncommon complication of pregnancy.
However, it is the most frequent organ dysfunction associated with obstetric
admissions to an intensive care unit. The obstetric population is a different
group due to its physiology and the presence of the fetus that lacks evidence
in the literature within the subject of ventilatory support. Noninvasive
positive pressure ventilation (NIPPV) is often avoided due to the lack of
knowledge on the safety and efficacy of this modality. Currently, there are no guidelines for the management of respiratory failure in
pregnancy. Objectives: To provide evidence in support of the use of
NIPPV as a safe and reasonable modality for pregnant patients with respiratory
failure. Methods: We retrospectively reviewed medical records of 29
pregnant patients of the Obstetric Critical Care Unit of a tertiary hospital in
Panama City who received NIPPV from 2013 to 2015. Failure to response was
defined as the lack of increase in the paO2/FiO2 ratio or clinical deterioration 6 hours after initiating NIPPV. Demographics,
indication for NIPPV, duration of treatment, as well as maternal and fetal
outcomes were collected. Measurements and Main Results: Mean age was 28.4 ± 6 years, mean body mass index 27.4 ± 3.3, and mean
gestational age at admission was 305/7 ± 5 weeks. Twenty-four
patients (82.8%) met the criteria for acute lung injury (ALI) and an additional
two (6.9%) for acute respiratory distress syndrome (ARDS). The…
Read the paper
Related studies
- Penicillins for Treatment of Pneumococcal Pneumonia: Does In Vitro Resistance Really Matter?
- Thiophenes—Naturally Occurring Plant Metabolites: Biological Activities and In Silico Evaluation of Their Potential as Cathepsin D Inhibitors
- Inhalable Mannosylated Rifampicin–Curcumin Co-Loaded Nanomicelles with Enhanced In Vitro Antimicrobial Efficacy for an Optimized Pulmonary Tuberculosis Therapy
- Development and validation of microbial bioassay for quantification of Levofloxacin in pharmaceutical preparations
- GC-MS Analysis and Biomedical Therapy of Oil from n-Hexane Fraction of Scutellaria edelbergii Rech. f.: In Vitro, In Vivo, and In Silico Approach
- Propranolol, chlorpromazine and diclofenac restore susceptibility of extensively drug-resistant (XDR)-Acinetobacter baumannii to fluoroquinolones
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.