Probiotic as an adjuvant preventive treatment for ventilator associated pneumonia: an evidence-based case report
Abstract
Background and objectives : Ventilator-associated pneumonia (VAP) is one of the most frequent nosocomial infections in patients requiring mechanical ventilation. It leads to prolonged duration of mechanical ventilation and ICU stay that is associated with a high rate of mortality, and the increase of healthcare burden. There have been various attempts to reduce the incidence of VAP including the use of antibiotics, but neither of these has conclusively shown to be beneficial. Probiotics have preventive effects in VAP through the suppression of pathogenic bacteria, enhancement of innate immunity, and promotion of epithelial barrier function. This study aimed to find out the efficacy of probiotic as adjuvant preventive treatment in patients with high risk of VAP.
How strong is the evidence?
Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- Penicillins for Treatment of Pneumococcal Pneumonia: Does In Vitro Resistance Really Matter?
- Thiophenes—Naturally Occurring Plant Metabolites: Biological Activities and In Silico Evaluation of Their Potential as Cathepsin D Inhibitors
- Inhalable Mannosylated Rifampicin–Curcumin Co-Loaded Nanomicelles with Enhanced In Vitro Antimicrobial Efficacy for an Optimized Pulmonary Tuberculosis Therapy
- Development and validation of microbial bioassay for quantification of Levofloxacin in pharmaceutical preparations
- GC-MS Analysis and Biomedical Therapy of Oil from n-Hexane Fraction of Scutellaria edelbergii Rech. f.: In Vitro, In Vivo, and In Silico Approach
- Propranolol, chlorpromazine and diclofenac restore susceptibility of extensively drug-resistant (XDR)-Acinetobacter baumannii to fluoroquinolones
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.