Presence of Sildenafil and Tadalafil in Herbal Medicinal Products Claimed to Treat Erectile Dysfunction in Nyamagana and Ilemela Districts, Mwanza, Tanzania
Abstract
Background: Herbal products are increasingly utilized for various conditions, including erectile dysfunction (ED), due to their minimal side effects, affordability, and natural properties. Phosphodiesterase type 5 inhibitors (PDE 5is) such as sildenafil citrate, tadalafil, vardenafil hydrochloride, and avanafil are synthetic oral medications approved for ED treatment. However, multiple studies have highlighted the contamination of herbal aphrodisiacs with PDE 5i or their conventional analogs. This study evaluated the contamination of aphrodisiac-claimed herbal products available in Mwanza, Tanzania. Method: A total of 40 herbal product samples were collected from local vendors and analyzed by high-performance thin layer chromatography (HPTLC). Chromatography was performed on a 20 × 10 cm aluminum-backed plate coated with analytical-grade silica gel 60 F254. The plates were developed on a 20 × 20 cm 30-min presaturated twin trough tank containing chloroform (9 mL), methanol (1 mL), and diethylamine (0.1 mL) as the mobile phase. The developed plates were scanned at the wavelengths of 292 and 284 nm for sildenafil and tadalafil, respectively. Results: Out of 40 herbal product samples analyzed, 25 samples (62.5%) were found to be adulterated. Among the adulterated samples, 2 (8%) were contaminated with sildenafil, 9 (36%) with tadalafil, and 14 (56%) with both sildenafil and tadalafil. Quantitative analysis indicated that two samples (12.5%) of the sildenafil-adulterated samples…
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