Comparison of different dosages in treating pneumonia of rat model with levofloxacin
Abstract
Aim To compare different dosages of levofloxacin in treating pneumonia of rat model.Methods 40 SD rats which were infected with standard strains of Escherichia coli(ATCC25922) for pneumonia were divided into two groups,according to the administration of different dosages.The rats of Group 1 were injected drug by Intravenous 4.5 mg·kg-1,Bid.The Group 2 were injected drug by Intravenous 9 mg·kg-1,Qd.The microbiological assay methods were used for determination of levofloxacin in serum.According to the group of levofloxacin pharmacokinetic-pharmacodynamic parameters the effects of different drug dosage were evaluated.Results The study showed that the average peak concentration of group 1(2.56±0.47) was significantly lower than that of group 2(4.29±0.95),but the average tough concentration of group 1(0.42±0.18) was higher than that of group 2(0.30±0.19).After treating pneumonia of the rats model,the bacterial culture results of lung tissue homogenate show the bacterial clearance rates were 82% and 83% respectively.There were no significant differences between the two groups after statistic analysis.Conclusions The two drug-administration programs are all ideal to treat the respiratory tract infection.There was no significant difference in efficacy in two groups.But the peak level of levofloxacin was higher,the number of infusion was less,more convenient treatment in group 2.
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