Study of delirium-type symptoms caused by levofloxacin in mice subjected to the inflammatory model induced by lipopolysaccharide
Abstract
Delirium is a clinical syndrome of acute brain dysfunction characterized by a state of confusion with decline in cognition that fluctuates over hours or days. It is associated with devastating stages, including increased hospital admissions and high rates of morbidity and mortality. It is correlated to several environmental, medicinal or pathological factors. However, the literature on delirium or psychosis associated with fluoroquinolone use is limited to case reports and the precise mechanism behind this association is unknown. Given the above, it is relevant to propose a possible mechanism for this brain dysfunction that may be caused by this class of antibiotics. To this end, healthy male Swiss mice (22 - 28g) were treated with levofloxacin (100mg/kg and 150mg/kg every 24 hours), or scolopolamine (1.5mg/kg), or vehicle intraperitoneally for 10 days. On the 9th day of treatment, some experimental groups received lipopolysaccharide (LPS) 0.5mg/kg intraperitoneally to activate the immune response. The animals were subjected to behavioral tests evaluating locomotor activity (Open Field), depressive-like behavior (Requested Swimming), cognitive performance (Y-Maze) and motor development (Rota-Rod). After the behavioral assessment, the cognitive areas (prefrontal cortex, striatum and hippocampus) were dissected to evaluate oxidative stress parameters (MDA, nitrite and GSH) and neurotransmitter levels (DOPA, DOPAC, GABA and Glutamate). Cytokines (TNF-α and IL-1β) were measured…
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