In-vitro Interaction Study of Levofloxacin with Metformin HCl and Losartan Potassium and Investigation of Antimicrobial Activity
Abstract
Background: This research work is a drug-drug interaction study between two widely used medications Levofloxacin and Metformin HCl as well as Losartan Potassium and this study is carried out at that time when they are used concomitantly (In- Vitro). Levofloxacin, this medication belongs to class of drugs known as quinolone antibiotics and is used to treat a wide range of gram positive (+) and gram-negative (-) bacterial infections. Metformin HCl is a medicine used to type 2 diabetes and gestational diabetes. Metformin is used with a proper diet and exercise program and possibly with other medications to control high blood sugar. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Objective: The research work aims to find out the quantitative interaction between Levofloxacin and Metformin HCl as well as Losartan Potassium and to identify how much interaction affects the effectiveness of Levofloxacin that has been done by Antimicrobial Analysis. Methodology: This research work ensures that there is a possible interaction between the Levofloxacin and Metformin HCl and Losartan Potassium which is confirmed by Job’s plot method as well as by the Antimicrobial study. In order to investigate the number of Losartan Potassium and Metformin HCl involved in the complexation with Levofloxacin complexes was demonstrated by exploiting various spectrophotometric methods. The ultraviolet studies of these complexes…
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