Blood culture positive sepsis and sensitivity pattern in NICU at a tertiary care neonatal centre
Abstract
Background: This study aims to study blood culture positive neonatal sepsis and the sensitivity pattern of pathogenic organisms in a tertiary neonatal care hospital.
Methods: This retrospective observational cohort study was done in a tertiary care hospital. All the blood culture positive neonatal sepsis cases, excluding neonates with multiple congenital malformations, diagnosed during March 2023 to August 2023 (6 months) were analyzed.
Results: A total of 73 neonatal sepsis cases were diagnosed, among them 40 (54.7%) cases of gram-positive sepsis. In present study 61.6% cases were early onset sepsis, 41 (56%) babies were preterm and 49 (67%) babies were inborn. Staphylococcus aureus and Acinetobacter were the most common organisms in early onset and late onset sepsis respectively. The sensitivity of Gram-negative bacilli to colistin, minocycline and levofloxacin was 90%, 84% and 78% respectively. The sensitivity of gram-positive organisms to linezolid, vancomycin and teicoplanin were 92%, 73% and 70% respectively. Mortality rate among culture positive sepsis was 16.4%.
Conclusions: In the practice of modern neonatal care, multidrug organisms are emerging. By practicing antibiotic stewardship, infants can be protected from future multidrug resistance organisms.
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence.
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