Antitubercular Treatment-induced Psychosis: A Systematic Review and Recommendations
Abstract
Review ARticle• What is the role of combining both strategies?• Should the offending drug be reintroduced after symptom resolution? IntroductIonTuberculosis (TB) remains one of the top 10 causes of death globally, 1 with India bearing the highest burden, accounting for a quarter of global TB cases and a third of related deaths. 2 While first-line antitubercular drugs (FLDs) such as isoniazid, rifampin, pyrazinamide, ethambutol, and streptomycin are used to treat drug-sensitive TB, cases of multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB) require secondline drugs (SLDs) such as kanamycin, levofloxacin, cycloserine, fluoroquinolones, ethionamide, capreomycin, p-aminosalicylic acid, moxifloxacin, clofazimine, linezolid, high-dose isoniazid, and amoxicillin-clavulanic acid.Many of these agents are known to cause neuropsychiatric side effects, including psychosis, yet the literature guiding the management of antitubercular drug-induced psychosis (ATDIP) remains sparse.This review evaluates the available literature to provide practical guidance for clinicians managing ATDIP.
How strong is the evidence?
Evidence Hub reads this as a systematic review. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
Read the paper
Related studies
- Ferulic acid regulates the AKT/GSK-3β/CRMP-2 signaling pathway in a middle cerebral artery occlusion animal model
- Novel Pharmacokinetic/Pharmacodynamic Parameters Quantify the Exposure–Effect Relationship of Levofloxacin against Fluoroquinolone-Resistant Escherichia coli
- Photochemical behavior of levofloxacin
- Correlation Between Dissolution Profiles of Salt-Form Drugs in Biorelevant Bicarbonate Buffer and Oral Drug Absorption: Importance of Dose/ Fluid Volume Ratio
- Evaluation of the synergistic potential and mechanisms of action for de novo designed cationic antimicrobial peptides
- Synthesis of [11C]levofloxacin
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.