Effect of Combined Treatment with Levofloxacin and Metformin on Diabetes-the Diabetes Related Behavioral and Biochemical Alterations
Abstract
Objective: The current experiment was conducted to investigate the combined effect of levofloxacin and metformin treatment on glucose level in blood, MDA, nitrite, level, anxiety of STZ+NAD induced diabetic rats.Methods: In this study, wistar rats have been used.After receiving a single dose of STZ+NAD (45 mg/kg, i.p.+ 50 mg/kg, i.p.), the rats developed diabetes.Glucose levels in diabetic rats exceed 200 mg/dl (verified on the third day).Saline was administered to non-diabetic rats (controls).The diabetic rats were given alone metformin (50 mg/kg, p.o.), levofloxacin (30 mg/kg, i.p.), or metformin + levofloxacin for fourteen days.The blood sample was obtained after the 14th day of therapy, and the rats were given to behavioral parameter to determine locomotor-activity and anxiousness level.Blood plasma sample has been separately and used for determination of nitrite and malondialdehyde (MDA) level.Results: It was observed that the combined treatment of metformin and levofloxacin significant rise glucose in blood of diabetic rats as compares to diabetic control (P < 0.05) and alone metformin treated diabetic rats (P < 0.001) at day-3 and day-7.Further, combined treatment of metformin and levofloxacin significantly reduce time spend at center of OFT (P < 0.001), significantly reduce time spend and entry made in light chamber of LDT (P < 0.001), significantly rise time spend in open arm and reduce the time spent in closed arm of EPM (P < 0.001) as compare to alone metformin…
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