Formulation and evaluation of levofloxacin ophtalmic insitu GEL
Abstract
The present study focuses on the formulation and evaluation of Levofloxacin ophthalmic in situ gel for the effective treatment of ocular infections. Conventional eye drops show poor bioavailability due to rapid tear drainage and short pre corneal residence time. To overcome these limitations, an in-situ gelling system was developed to enhance ocular retention and provide sustained drug release. The Formulation was prepared using thermo sensitive and or pH-sensitive polymers polymers that exhibit sol-to- gel phase transitions due to change in specific physicochemical parameter such as (pH, temperature), in their environment, the cul-de-sac in this case such as carbopol 934. The prepared formulations were evaluated for clarity, pH, viscosity, drug content, gelation capacity, in vitro drug release, sterility, Rheological, Isotonicity test, Microbial Assay and stability test was performed. All formulations were found to be clear, with pH within the acceptable ocular range and uniform drug content. Viscosity studies confirmed sol-to-gel transition under physiological conditions. In vitro drug release studies demonstrated sustained release of Levo-0floxacin over an extended period compared to conventional ophthalmic solutions. The optimized formulation showed appropriate gelation behavior, prolonged drug release, and satisfactory stability. The study concludes that levofloxacin ophthalmic in situ gel is a promising alternative to conventional eye drops, offering improved…
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