Formulation, Optimisation, and Characterisation of a Novel Nanoparticle Drug Delivery System for Levofloxacin
Abstract
The present study was aimed to formulate and characterise levofloxacin-loaded polymeric nanoparticles for improved ocular drug delivery. The nanoparticles were prepared using the oil-in-water (O/W) emulsification solvent evaporation technique, employing polyvinyl alcohol (PVA) as a stabilising agent and poly (lactic-co-glycolic acid) (PLGA) as the polymeric carrier. The developed formulations were evaluated for various physicochemical parameters including particle size, zeta potential, drug loading, encapsulation efficiency, and in vitro drug release. Among all formulations, batch F3 exhibited optimal characteristics with a particle size of 5.62 nm, zeta potential of −18 mV, and high encapsulation efficiency of 96.26%, indicating good stability and efficient drug entrapment. F3 achieved 89.38% drug release at 12 hours and 103.52% at 24 hours, indicating complete and efficient drug release. These findings suggest that the optimised nanoparticle formulation possesses desirable physicochemical properties and sustained drug release behaviour, making it a promising candidate for enhanced ocular delivery of levofloxacin
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