Evaluation of the efficacy of combination of biapenem and levofloxacin in the treatment of severe pneumonia in patients with multidrug-resistant Pseudomonas aeruginosa
Abstract
Objective
To observe the clinical efficacy of combination of biapenem and levofloxacin in the treatment of severe pneumonia caused by multi-drug resistant Pseudomonas albuginea.In order to provide effective treatment for the patients with severe pneumonia resulted from resistant Pseudomonas albuginea.
Methods
Sixty patients with severe pneumonia were enrolled in this study.All patients had multiple drug resistant Pseudomonas aeruginosa infection.They were randomly divided into two groups according to the digital table method, 30cases in each group.All patients were treated with mechanical ventilation, anti-infection, phlegm, asthma and hemodynamic stability.The control group was treated with cefperazone-sulbactam and levofloxacin.The treatment group was treated with biapenem and levofloxacin.The body temperature, white blood cell count(WBC) and procalcitonin(PCT) level, oxygenation index(PaO2/FiO2), the total clinical effective rate, pulmonary rales disappeared time and the time of chest radiograph showing the pulmonary exudate absorption significantly were compared before treatment and 7 days after treatment.
Results
After treatment, the WBC, body temperature, PCT, PaO2/FiO2 of the control group were (13.16±2.89)109/L, (37.58±0.92)℃, (195.36±10.63), (9.36±1.56)μg/L, respectively, which of the treatment group were (5.36±2.65)×109/L, (36.41±0.52)℃, (235.14±8.65), (5.63±1.69)μg/L, respectively, and the differences between the two groups were statistically significant(t=2.72,…
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