Pharmacokinetics and Tissue Residue Study of Levofloxacin Following Multiple Dose Intramuscular Administration in Poultry
Abstract
The present study was undertaken to investigate the pharmacokinetics and tissue residue study of levofloxacin @ 10.0 mg.kg-1 in poultry (n=16) following multiple (5) dose intramuscular (i.m.) administration. The concentration of levofloxacin in plasma and tissue of these animals were analysed by HPLC. Following multiple dose i.m. administration volume of distribution, clearance, AUC and elimination half-life after first dose was 5925.34 ml.kg-1, 1401.3 ml.h-1.kg-1, 7.32 h.µg.ml-1 and 2.97h, respectively and 5193.88 ml.kg-1, 1663.16 ml.h-1.kg-1, 6.42 h.µg.ml-1 and 2.30h after the last dose. Residue of levofloxacin was present in kidney, liver and muscle upto 72h post administration of levofloxacin with highest concentration of 0.14µg.g-1in kidney. The limit of detection in tissue was 0.02µ.g-1.
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